Relationships between opiate receptor binding and analgetic properties of prodine-type compounds.
نویسندگان
چکیده
The receptor binding affinities of some diastereoisomeric prodine analgoues have been compared with their analgetic activities determined by the hot-plate test in mice. The close correlation found between these potencies indicates that the relative analgetic activities of the alpha/beta isomers are determined primarily by the appropriate association to the receptor sites.
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ورودعنوان ژورنال:
- Journal of medicinal chemistry
دوره 20 2 شماره
صفحات -
تاریخ انتشار 1977